Bioactive Sesquiterpenes from the Essential Oil of Thuja orientalis
- Authors
- Kim, Ki Hyun; Moon, Eunjung; Kim, Sun Yeou; Choi, Sang Un; Son, Mi Won; Choi, Sang Zin; Lee, Kang Ro
- Issue Date
- Nov-2013
- Publisher
- GEORG THIEME VERLAG KG
- Keywords
- Thuja orientalis; Cupressaceae; sesquiterpene; cytotoxicity; anti-inflammation
- Citation
- PLANTA MEDICA, v.79, no.17, pp.1680 - 1684
- Journal Title
- PLANTA MEDICA
- Volume
- 79
- Number
- 17
- Start Page
- 1680
- End Page
- 1684
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/14171
- DOI
- 10.1055/s-0033-1350952
- ISSN
- 0032-0943
- Abstract
- A phytochemical investigation on the essential oil of Thuja orientalis resulted in the isolation and identification of three new sesquiterpenes, 3-methoxy-4-epoxythujopsane (1), (3,15)-4-epoxythujopsene (2), and (3,4)-thujopsen-2,15-diol (3), together with eight known sesquiterpenoids (4-11). The structures of these new compounds were elucidated based on spectroscopic data analyses including extensive 2D-NMR data and HR-ESIMS. The full assignments of H-1 and C-13 NMR chemical shifts for thujopsadiene (4) were obtained by 2D-NMR for the first time. All compounds (1-11) showed antiproliferative activities against the SK-OV-3 and SK-MEL-2 cell lines with IC50 values of 5.85-28.64 mu M. In addition, compounds 1, 3, 4, 7, 8, and 9 significantly inhibited nitric oxide production in lipopolysaccharide-activated BV-2 cells with IC50 values of 3.93-17.85 mu M without cell toxicity.
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