Proanthocyanidins from Spenceria ramalana and Their Effects on AGE Formation in Vitro and Hyaloid-Retinal Vessel Dilation in Larval Zebrafish in Vivo
- Authors
- Lee, Ik-Soo; Yu, Song Yi; Jung, Seung-Hyun; Lee, Yu-Ri; Lee, Yun Mi; Kim, Joo-Hwan; Sun, Hang; Kim, Jin Sook
- Issue Date
- Oct-2013
- Publisher
- AMER CHEMICAL SOC
- Citation
- JOURNAL OF NATURAL PRODUCTS, v.76, no.10, pp.1881 - 1888
- Journal Title
- JOURNAL OF NATURAL PRODUCTS
- Volume
- 76
- Number
- 10
- Start Page
- 1881
- End Page
- 1888
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/14280
- DOI
- 10.1021/np400442b
- ISSN
- 0163-3864
- Abstract
- Three new A-type proanthocyanidins (1-3), ent-epiafzelechin-(2 alpha -> O -> 7,4 alpha -> 8)-ent-afzelechin 3'-O-beta-D-glycopyranoside (1), ent-epiafzelechin-(2 alpha -> O -> 7,4 alpha -> 8)-ent-epiafzelechin-(2 alpha -> O -> 7,4 alpha -> 8)-ent-afzelechin (2), and ent-epiafzelechin-(2 alpha -> O -> 7,4 alpha -> 8) -ent-epiafzelechin-(2 alpha -> O -> 7,4 alpha -> 8)-ent-afzelechin (3), and three known compounds (4-6) were isolated from the whole plant of Spenceria ramalana. The structures of the new proanthocyanidins were established by spectroscopic and chemical studies. The inhibitory effects of compounds 1-6 on the formation of advanced glycation end products were examined in vitro. Compounds 3 and 6 showed the strongest inhibition, with IC50 values of 17.4 +/- 0.5 and 14.1 +/- 1.6 mu M, respectively. The effects of these isolates on the dilation of hyaloid-retinal vessels induced by high glucose (HG) in larval zebrafish were also investigated. Compound 3 reduced the dilation of HG-induced hyaloid-retinal vessels most effectively. This compound reduced the diameters of HG-induced hyaloid-retinal vessels by about 157.7% and 164.1% at 10 and 20 mu M, respectively, versus the HG-treated control group.
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