The Impact of Inosine Triphosphatase Variants on Hemoglobin Level and Sustained Virologic Response of Chronic Hepatitis C in Korean
- Authors
- Kim, Ju Seung; Ahn, Sung-Min; Jung, Young Kul; Kwon, Oh Sang; Kim, Yun Soo; Choi, Duck Joo; Kim, Ju Hyun
- Issue Date
- Aug-2013
- Publisher
- KOREAN ACAD MEDICAL SCIENCES
- Keywords
- Hepatitis C, Chronic; Ribavirin; Anemia; ITPA; IL28B
- Citation
- JOURNAL OF KOREAN MEDICAL SCIENCE, v.28, no.8, pp.1213 - 1219
- Journal Title
- JOURNAL OF KOREAN MEDICAL SCIENCE
- Volume
- 28
- Number
- 8
- Start Page
- 1213
- End Page
- 1219
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/14405
- DOI
- 10.3346/jkms.2013.28.8.1213
- ISSN
- 1011-8934
- Abstract
- Two variants of the inosine triphosphatase (ITPA: rs1127354, rs7270101) gene cause ITPA deficiency and protect against the hemolytic toxicity of ribavirin. We investigated the clinical significance of ITPA variants in Korean patients treated with pegylated interferon (PEG-IFN) plus ribavirin. Of the 133 patients, 108 were CC and 25 were non-CC at rs1127354 (groups A and B, respectively). On the other hand, at rs7270101 all 133 were AA. The mean values of Hemoglobin (Hgb) after 4, 8, and 12 weeks of treatment in groups A and B were 12.2 and 14.0, 11.8 and 13.2, and 11.5 and 12.9, respectively (P = 0.001, 0.036, 0.036). Sustained virologic response (SVR) was achieved in 67.8% (40/59) of genotype 1 patients and in 75% (27/36) of non-genotype 1 patients. Regarding ITPA variants, SVR was achieved by 66% and 80% of genotype 1 (P = 0.282), and by 78% and 71% (P = 0.726) of non-genotype 1. SVR was not significantly different in groups A and B. In conclusion, non-CC at rs1127354 without involvement of rs7270101 is strongly associated with protection from ribavirin-induced anemia, however, ITPA genotype is not associated with SVR.
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