The protective effect of Prunella vulgaris ethanol extract against vascular inflammation in TNF-alpha-stimulated human aortic smooth muscle cells
- Authors
- Park, Sun Haeng; Koo, Hyun Jung; Sung, Yoon Young; Kim, Ho Kyoung
- Issue Date
- 31-Jul-2013
- Publisher
- KOREAN SOCIETY BIOCHEMISTRY & MOLECULAR BIOLOGY
- Keywords
- Adhesion molecules; Atherosclerosis; Human aortic smooth muscle cells; Inflammation; Prunella vulgaris
- Citation
- BMB REPORTS, v.46, no.7, pp.352 - 357
- Journal Title
- BMB REPORTS
- Volume
- 46
- Number
- 7
- Start Page
- 352
- End Page
- 357
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/14417
- DOI
- 10.5483/BMBRep.2013.46.7.214
- ISSN
- 1976-6696
- Abstract
- Atherosclerosis, which manifests as acute coronary syndrome, stroke, and peripheral arterial diseases, is a chronic inflammatory disease of the arterial wall. Prunella vulgaris, a perennial herb with a worldwide distribution, has been used as a traditional medicine in inflammatory disease. Here, we investigated the effects of P. vulgaris ethanol extract on TNF-alpha-induced inflammatory responses in human aortic smooth muscle cells (HASMCs). We found that P. vulgaris ethanol extract inhibited adhesion of monocyte/macrophage-like THP-1 cells to activated HASMCs. It also decreased expression of intercellular adhesion molecule-1, vascular cell adhesion molecule-1, E-selectin and ROS, No production in TNF-alpha-induced HASMCs and reduced NF-kB activation. Furthermore, P. vulgaris extract suppressed TNF-alpha-induced phosphorylation of p38 mitogen-activated protein kinase (MAPK) and extracellular signal-regulated kinase (ERK). These results demonstrate that P. vulgaris possesses anti-inflammatory properties and can regulate TNF-alpha-induced expression of adhesion molecules by inhibiting the p38 MAPK/ERK signaling pathway.
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