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Anti-neuroinflammatory diarylheptanoids from the rhizomes of Dioscorea nipponica
- Authors
- Woo, Kyeong Wan; Moon, Eunjung; Kwon, Oh Wook; Lee, Sung Ok; Kim, Sun Yeou; Choi, Sang Zin; Son, Mi Won; Lee, Kang Ro
- Issue Date
- 1-Jul-2013
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Keywords
- Dioscorea nipponica; Dioscoreaceae; Diarylheptanoids; Nitric oxide; Anti-neuroinflammation
- Citation
- BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.23, no.13, pp.3806 - 3809
- Journal Title
- BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Volume
- 23
- Number
- 13
- Start Page
- 3806
- End Page
- 3809
- ISSN
- 0960-894X
- Abstract
- In a continuing search for bioactive constituents from Dioscoreaceae medicinal plants, two new cyclic diarylheptanoids, diosniponol A (1) and B (2), together with 10 known compounds (3-12) were isolated from the rhizomes of Dioscorea nipponica. The structures of these new compounds were determined by spectroscopic analyses, including extensive two-dimensional nuclear magnetic resonance, high-resolution mass spectrometry, and optical rotation. All isolated compounds 1-12 were evaluated for their effects on nitric oxide (NO) production in murine microglia cell line BV-2. Compounds 8 and 11 showed potent inhibitory activities on NO production (IC50 13.36 and 14.36 mu M, respectively) without cell toxicity in lipopolysaccharide-activated BV-2 cells. (C) 2013 Elsevier Ltd. All rights reserved.
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Related Researcher
- Kim, Sun Yeou
- Pharmacy (Dept.of Pharmacy)