Diabetes-Free Survival in Patients Who Underwent Islet Autotransplantation After 50% to 60% Distal Partial Pancreatectomy for Benign Pancreatic Tumors
- Authors
- Jin, Sang-Man; Oh, Seung-Hoon; Kim, Soo Kyoung; Jung, Hye Seung; Choi, Seong-Ho; Jang, Kee-Taek; Lee, Kyu Taek; Kim, Jae Hyeon; Lee, Myung-Shik; Lee, Moon-Kyu; Kim, Kwang-Won
- Issue Date
- 15-Jun-2013
- Publisher
- LIPPINCOTT WILLIAMS & WILKINS
- Keywords
- Islet transplantation; Pancreatectomy; Islet isolation
- Citation
- TRANSPLANTATION, v.95, no.11, pp.1396 - 1403
- Journal Title
- TRANSPLANTATION
- Volume
- 95
- Number
- 11
- Start Page
- 1396
- End Page
- 1403
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/14471
- DOI
- 10.1097/TP.0b013e31828c0c29
- ISSN
- 0041-1337
- Abstract
- Background. Several retrospective studies with short-termfollow-up have demonstrated a low rate of new-onset diabetes after distal pancreatectomy for benign pancreatic tumors. We sought to determine the long-termdiabetes-free survival of patients who underwent islet autotransplantation (IAT) after distal pancreatectomy and to identify any associations between the isolation parameters of autologous islets and diabetes-free survival. Methods. Among the 37 nondiabetic patients who underwent 50% to 60% partial pancreatectomy, 20 underwent IAT (IAT group; median follow-up period, 61 months). In the IAT group, diabetes-free survival was determined based on annual oral glucose tolerance tests, fasting blood glucose, and hemoglobin A(1C). Results. The 7-year diabetes-free survival rate was 51% in the IAT group (median follow-up period, 61 months) and 45% in the 37 study subjects. Diabetes-free survival was significantly prolonged when islet yield per gram of pancreas weight was more than 5154 islet equivalents (IEQ)/g, even in patients with prediabetes and high insulin resistance who had a markedly high rate of diabetes development. The proportion of patients with impaired glucose tolerance at 2 years after distal pancreatectomy was 12 of 16 in the control group, 6 of 7 in patients with islet yields of less than 5154 IEQ/g, and 3 of 11 in patients with islet yields of more than 5154 IEQ/g (P=0.019). Conclusions. Partial (50%-60%) pancreatectomy for benign pancreatic tumors had a major metabolic consequence, especially in patients with prediabetes and high insulin resistance. In this setting, prolonged diabetes-free survival was observed in patients who underwent IAT when a high islet yield per gram of pancreas was achieved.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - ETC > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/14471)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.