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Effects of beta-glucans from Coriolus versicolor on macrophage phagocytosis are related to the Akt and CK2/Ikaros
- Authors
- Kang, Se Chan; Koo, Hyun Jung; Park, Sulkyung; Lim, Jung Dae; Kim, Ye-Jin; Kim, Taeseong; Namkoong, Seung; Jang, Ki-Hyo; Pyo, Suhkneung; Jang, Seon-A; Sohn, Eun-Hwa
- Issue Date
- Jun-2013
- Publisher
- ELSEVIER SCIENCE BV
- Keywords
- Beta-glucan; Coriolus versicolor; Dectin-1; Phagocytic activity; RAW264.7
- Citation
- INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, v.57, pp.9 - 16
- Journal Title
- INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
- Volume
- 57
- Start Page
- 9
- End Page
- 16
- ISSN
- 0141-8130
- Abstract
- Coriolus versicolor has been known to be an immune stimulator effects. For further understanding of the phagocytic activity and the intracellular mechanisms of beta-glucan from C versicolor (CVG), we examined the phagocytic activity, phosphorylation of Akt and CK2, nucleus translocation of p65 and Ikaros activity in beta-glucan-treated macrophages using RT-PCR, western blotting, and IP assay. The role of Ikaros in regulating phagocytic effects of CVG was also determined using Ikaros dominant negative isoform cells. This study suggests that CIC2/Ikaros are positive regulators and novel signaling pathway involved in phagocytosis and contributes to elucidating the mechanism underlying phagocytic activity induced by beta-glucan. (C) 2013 Elsevier B.V. All rights reserved.
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