Reduced Beta-Catenin Expression in the Hippocampal CA1 Region Following Transient Cerebral Ischemia in the Gerbil
- Authors
- Cho, Jeong-Hwi; Yan, Bing Chun; Lee, Young Joo; Park, Joon Ha; Ahn, Ji Hyeon; Kim, In Hye; Lee, Jae-Chul; Kim, Young-Myeong; Lee, Bonghee; Cho, Jun Hwi; Won, Moo-Ho
- Issue Date
- May-2013
- Publisher
- SPRINGER/PLENUM PUBLISHERS
- Keywords
- Ischemia-reperfusion injury; Dendrite damage; Microtubule-associated protein 2; Synaptic plasticity; Beta-catenin
- Citation
- NEUROCHEMICAL RESEARCH, v.38, no.5, pp.1045 - 1054
- Journal Title
- NEUROCHEMICAL RESEARCH
- Volume
- 38
- Number
- 5
- Start Page
- 1045
- End Page
- 1054
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/14567
- DOI
- 10.1007/s11064-013-1015-2
- ISSN
- 0364-3190
- Abstract
- Beta-catenin, a transcription factor, plays a critical role in cell survival and degradation after stroke. In this study, we examined changes of expression in beta-catenin in the hippocampal CA1 region of the gerbil following 5 min of transient cerebral ischemia. We observed neuronal damage using cresyl violet staining, neuronal nuclei immunohistochemistry and Fluro-Jade B immunofluorescence. Four days after ischemia-reperfusion (I-R), most of pyramidal cells in the CA1 region were damaged. In addition, early damage in dendrites was detected 1 day after I-R by immunohistochemical staining for microtubule-associated protein 2 (MAP-2), and MAP-2 immunoreactivity was hardly detected in the CA1 region 4 days after I-R. We found that beta-catenin (a synapse-enriched cell adhesion molecule) was well expressed in dendrites before I-R. Its immunoreactivity was well colocalized with MAP-2. Chronological change of beta-catenin immunoreactivity was novelty in the present study. Twelve hours after I-R, its immunoreactivity was decreased in the stratum radiatum of the CA1 region, however, its immunoreactivity was increased 1 and 2 days after I-R, and decreased sharply 4 days after I-R. However, we did not find any change in beta-catenin immunoreactivity in the CA2 and CA3 region. In brief, we suggest that early change of beta-catenin expression in the stratum pyramidale of ischemic hippocampal CA1 region is associated with early dendrite damage following transient cerebral ischemia.
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