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Nocapyrones H-J, 3,6-Disubstituted alpha-Pyrones from the Marine Actinomycete Nocardiopsis sp KMF-001
- Issue Date
- May-2013
- Publisher
- PHARMACEUTICAL SOC JAPAN
- Keywords
- nocapyrone H; nocapyrone I; nocapyrone J; Nocardiopsis sp.; neuro-protective effect
- Citation
- CHEMICAL & PHARMACEUTICAL BULLETIN, v.61, no.5, pp.511 - 515
- Journal Title
- CHEMICAL & PHARMACEUTICAL BULLETIN
- Volume
- 61
- Number
- 5
- Start Page
- 511
- End Page
- 515
- ISSN
- 0009-2363
- Abstract
- Three new 3,6-disubstituted alpha-pyrones, nocapyrones H-J (1-3), were isolated from the marine actinomycete Nocardiopsis sp. KMF-001. Their structures were assigned to be 3-alkylated 6-(1-methyl-1-propenyl)-2H-pyran-2-ones on the basis of UV, MS, NMR, and high resolution (HR)-FAB-MS analyses. Nocapyrone H (1) reduced the pro-inflammatory factor such as nitric oxide (NO), prostaglandin E-2 (PGE(2)) and interleukin-1 beta (IL-1 beta). Moreover, nocapyrone H showed 5.82% stronger inhibitory effect on NO production than chrysin at a concentration of 10 mu M in lipopolysaccharide (LPS)-stimulated BV-2 microglial cells.
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Related Researcher
- Kim, Sun Yeou
- Pharmacy (Dept.of Pharmacy)