Lanostane Triterpenoids from the Mushroom Naematoloma fasciculare
- Authors
- Kim, Ki Hyun; Moon, Eunjung; Choi, Sang Un; Kim, Sun Yeou; Lee, Kang Ro
- Issue Date
- May-2013
- Publisher
- AMER CHEMICAL SOC
- Citation
- JOURNAL OF NATURAL PRODUCTS, v.76, no.5, pp.845 - 851
- Journal Title
- JOURNAL OF NATURAL PRODUCTS
- Volume
- 76
- Number
- 5
- Start Page
- 845
- End Page
- 851
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/14593
- DOI
- 10.1021/np300801x
- ISSN
- 0163-3864
- Abstract
- In our continuing search for structurally interesting and bioactive metabolites from Korean wild mushrooms, bioassay-guided fractionation and a chemical investigation of the MeOH extracts of the fruiting bodies of the mushroom Naematoloma fasciculare resulted in the isolation of four new lanostane triterpenoids (1-4), together with 11 known compounds (5-15). The structures of 1-5 were determined by a combination of ID and 2D NMR and HRMS. The absolute configuration of the 3-hydroxy-3-methylglutaryl group as a side chain in 1 and 2 was determined by the alkaline methanolysis method. The full NMR data assignment of the known compound fasciculol G (S) is reported for the first time. Compounds 1-15 were tested for their antiproliferative activities against four human cancer cell lines (A549, SK-OV-3, SK-MEL-2, and HCT-15) and evaluated for their inhibitory effects on nitric oxide production in a lipopolysaccharide-activated murine microglial cell line.
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