黃連 추출물이 대식세포의 면역단백질 생성에 미치는 영향Effect of Coptidis Rhizoma Extract on Cytokine Production of Mouse Macrophages
- Other Titles
- Effect of Coptidis Rhizoma Extract on Cytokine Production of Mouse Macrophages
- Authors
- 김복기; 한효상; 이영종
- Issue Date
- 2013
- Publisher
- 대한한의학방제학회
- Keywords
- Coptidis Rhizoma; Macrophage; Cyokine; Interleukin-1α; Interleukin-17
- Citation
- 대한한의학 방제학회지, v.21, no.2, pp.81 - 89
- Journal Title
- 대한한의학 방제학회지
- Volume
- 21
- Number
- 2
- Start Page
- 81
- End Page
- 89
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/15155
- DOI
- 10.14374/HFS.2013.21.2.081
- ISSN
- 1229-1218
- Abstract
- Objectives : The purpose of this study is to observe the effect of Coptidis Rhizoma (CCE-extract of C. chinensis Rhizome) in induction of immune protein on mouse macrophages.
Methods : To analyze cytokines interleukin(IL)-1α, IL-3, IL-9, IL-12p40, IL-13, IL-17, Monocyte Chemoattractant Protein(MCP)-1 induced by macrophages, mouse macrophages were incubated with CCE and was measured.
Results : IL-1α measurement, CCE showed significant inhibition only at concentration level of 200 ㎍/mL. IL-3, MCP-1 measurement, CCE showed significant inhibition only at concentration level of 100, 200 ㎍/mL. IL-9 measurement, CCE showed significant inhibition only at concentration level of 50 ㎍/mL. IL-13 measurement, CCE showed significant inhibition only at concentration level of 50, 100, 200 ㎍/mL. The IL-12p40, IL-17 levels indicated no changes at 25, 50, 100, 200 ㎍/mL on mouse macrophages.
Conclusions : CCE did not significantly increased inflammatory cytokines IL-1α, IL-3, IL-9, IL-12p40, IL-13, IL-17, Monocyte Chemoattractant Protein(MCP)-1 on mouse macrophages. It was verified CCE does not trigger cytokine related hypersensitivity reaction of organism or exacerbation of acute/chronic inflammatory disease.
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