Securinega Alkaloids from the Twigs of Securinega suffruticosa and Their Biological Activities
- Authors
- Park, Kyoung Jin; Kim, Chung Sub; Khan, Zahra; Oh, Joonseok; Kim, Sun Yeou; Choi, Sang Un; Lee, Kang Ro
- Issue Date
- May-2019
- Publisher
- AMER CHEMICAL SOC
- Citation
- JOURNAL OF NATURAL PRODUCTS, v.82, no.5, pp.1345 - 1353
- Journal Title
- JOURNAL OF NATURAL PRODUCTS
- Volume
- 82
- Number
- 5
- Start Page
- 1345
- End Page
- 1353
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/1539
- DOI
- 10.1021/acs.jnatprod.9b00142
- ISSN
- 0163-3864
- Abstract
- Seven new Securinega alkaloids, securingines A-G (1-7), together with seven known analogues (8-14), were isolated from the twigs of Securinega suffruticosa. Their chemical structures were elucidated by a combined approach of spectroscopic analysis, chemical methods, ECD calculations, and DP4+ probability analysis. The full NMR assignments and the absolute configuration of compound 8 are also reported. In addition, all the isolated phytochemicals (1-14) were assessed for their cytotoxic, anti-inflammatory, and potential neuroprotective activities. Compound 4 showed cytotoxic activity (IC50 values of 1.5-6.8 mu M) against four human cell lines (A549, SK-OV-3, SK-MEL-2, and HCT15). Compounds 3, 10, 12, and 13 showed potent inhibitory effects on nitric oxide production (IC50 values of 12.6, 12.1, 1.1, and 7.7 mu M, respectively) in lipopolysaccharide-stimulated murine microglia BV-2 cells. Compound 5 exhibited a nerve growth factor production effect (172.6 +/- 1.2%) in C6 glioma cells at 20 mu g/mL.
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