熟地養筋湯 추출물이 흰쥐 좌골신경 손상 후에 기능회복과 염증 매개 인자 발현에 미치는 영향Effect of Aqueous Extract of Sukjiyanggeun-Tang(shú dˋl yǎngj l̄n-tāng) on Functional Recovery and Expressions of Inflammatory Mediators after Sciatic Nerve Crushed Injury in Rat
- Other Titles
- Effect of Aqueous Extract of Sukjiyanggeun-Tang(shú dˋl yǎngj l̄n-tāng) on Functional Recovery and Expressions of Inflammatory Mediators after Sciatic Nerve Crushed Injury in Rat
- Authors
- 장건; 송윤경; 임형호
- Issue Date
- 2013
- Publisher
- 한방재활의학과학회
- Keywords
- Sukjiyanggeun-Tang(shúdˋlyǎngj l̄n-tāng ); Sciatic nerve injury; Axonal Regeneration; Sciatic functional index; COX-2; iNOS; TNF-α
- Citation
- 한방재활의학과학회지, v.23, no.2, pp.33 - 48
- Journal Title
- 한방재활의학과학회지
- Volume
- 23
- Number
- 2
- Start Page
- 33
- End Page
- 48
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/15575
- ISSN
- 1229-1854
- Abstract
- Objectives :Peripheral nerve injuries are commonly encountered clinical problems and often result in severe functional deficits. Sukjiyanggeun-Tang(shúdˋlyǎngj l̄n-tāng ), in oriental medicine, has been used to treat various musculoskeletal disorders.
Methods :In the present study, the effects of aqueous extract of Sukjiyanggeun-Tang(shúdˋlyǎngj l̄n-tāng ) on functional recovery, severity of pain, and expressions of neurofilament, cycloxygenease-2(COX-2), inducible nitric oxide synthase(iNOS), and tumor necrosis factor-α(TNF-α) following sciatic crushed nerve injury in rats were investigated. For this study, walking tract analysis, plantar test, western blot analysis for COX-2 iNOS, and TNF-α, and Immunofluorescence test for neurofilament were performed.
Results :In the present results, sciatic functional index(SFI) in walking tract analysis was significantly decreased following sciatic crushed nerve injury, and pain severity in plantar test was significantly increased. COX-2, iNOS and TNF-α expressions were increased whereas neurofilament expression was decreased by sciatic crushed nerve injury, In contrast, treatment with Sukjiyanggeun-Tang(shúdˋlyǎngj l̄n-tāng ) improved SFI in walking tract analysis and suppressed the pain severity in sciatic crushed nerve injury. Sukjiyanggeun-Tang(shúdˋlyǎngj l̄n-tāng ) treatment also suppressed COX-2, iNOS, and TNF-α expressions and enhanced the neurofilament expression in sciatic crushed nerve injury.
Conclusions :In the present study, we have shown that Sukjiyanggeun-Tang(shúdˋlyǎngj l̄n-tāng ) is the effective therapeutic modality to ameliorate the symptoms of sciatic crushed nerve injury.
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