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Bifunctional coumarin derivatives that inhibit transthyretin amyloidogenesis and serve as fluorescent transthyretin folding sensors
- Authors
- Myung, Nojoon; Connelly, Stephen; Kim, Boyoung; Park, Sung Jean; Wilson, Ian A.; Kelly, Jeffery W.; Choi, Sungwook
- Issue Date
- 2013
- Publisher
- ROYAL SOC CHEMISTRY
- Citation
- CHEMICAL COMMUNICATIONS, v.49, no.80, pp.9188 - 9190
- Journal Title
- CHEMICAL COMMUNICATIONS
- Volume
- 49
- Number
- 80
- Start Page
- 9188
- End Page
- 9190
- ISSN
- 1359-7345
- Abstract
- We describe coumarin derivatives that are non-fluorescent in aqueous buffers and that very selectively bind to transthyretin (TTR) in complex biological environments potently inhibiting TTR amyloidogenesis while also exhibiting sensitive off-on fluorescent sensing of the properly folded quaternary structure of TTR.
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Related Researcher
- Park, Sung Jean
- Pharmacy (Dept.of Pharmacy)