Dutasteride, who is it more effective for? Second to fourth digit ratio and the relationship with prostate volume reduction by dutasteride treatment
- Authors
- Kim, Tae Beom; Oh, Jin Kyu; Kim, Khae Hawn; Jung, Han; Yoon, Sang Jin; Lee, Min Sung; Kim, Soo Woong
- Issue Date
- Dec-2012
- Publisher
- WILEY-BLACKWELL
- Keywords
- benign prostatic hyperplasia; digit ratio dutasteride; prostate volume
- Citation
- BJU INTERNATIONAL, v.110, no.11C, pp.E857 - E863
- Journal Title
- BJU INTERNATIONAL
- Volume
- 110
- Number
- 11C
- Start Page
- E857
- End Page
- E863
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/15955
- DOI
- 10.1111/j.1464-410X.2012.11343.x
- ISSN
- 1464-4096
- Abstract
- OBJECTIVE To investigate the relationship between second to fourth digit ratio (hereafter the digit ratio) and prostate volume reduction by dutasteride treatment. PATIENTS AND METHODS A total of 142 men aged >= 40 years with a clinical diagnosis of benign prostatic hyperplasia and an enlarged prostate (prostate volume >= 30 mL) were prospectively enrolled. Before prostate-specific antigen (PSA) level determination and transrectal ultrasonography (TRUS), the lengths of the second and fourth digits of the right hand were measured by an investigator using a digital vernier calliper. Using TRUS, pre- and post-treatment prostate volume (PV1 and PV2) were measured by an uroradiologist who was unaware of finger lengths. We investigated the change in prostate volume and PSA level at least 6 months after the initiation of dutasteride therapy. RESULTS When the patients were divided into two groups according to digit ratio (A: digit ratio <0.95, n = 71; B: digit ratio >= 0.95, n = 71), there was a greater reduction in prostate volume in group B compared to group A (PV2 -PV1: -9.4 mL vs -13.2 mL, P = 0.042; [PV2 -PV1]/PV1: -17.5% vs -24.5%, P = 0.027; [PV2 -PV1]/duration: -1.1 mL/month vs-1.6 mL/month, P = 0.041; [PV2-PV1]/PV1/duration: -2.0%/month vs-3.0%/month, P = 0.016). Significant negative correlations were found between the digit ratio and reduction rate ([PV2 -PV1] /duration: r = -0.165, P = 0.049; [PV2 -PV1] /PV1/duration: r = -0.191, P = 0.023). CONCLUSIONS Patients with higher digit ratios respond well to dutasteride treatment. The results obtained in the present study suggest that the digit ratio is a predictor of the response to dutasteride treatment.
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