Cycloartane-Type Triterpenes from the Leaves of Homonoia riparia with VEGF-Induced Angiogenesis Inhibitory Activity
- Authors
- Lee, Iksoo; Kim, Junghyun; Kim, Young Sook; Yoo, Nam Hee; Kim, Chan-Sik; Jo, Kyuhyung; Kim, Joo-Hwan; Tran The Bach; Kim, Jin Sook
- Issue Date
- Jul-2012
- Publisher
- AMER CHEMICAL SOC
- Citation
- JOURNAL OF NATURAL PRODUCTS, v.75, no.7, pp.1312 - 1318
- Journal Title
- JOURNAL OF NATURAL PRODUCTS
- Volume
- 75
- Number
- 7
- Start Page
- 1312
- End Page
- 1318
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/16313
- DOI
- 10.1021/np300224k
- ISSN
- 0163-3864
- Abstract
- Six new cycloartane-type triterpenes (1-6), 24-methylenecydoartane-3 beta,6 beta,7 beta-triol (1), 24-methylenecycloartane-3 beta,6 beta,7 beta,16 beta-tetraol (2), 24-methylenecycloartane-3 beta,6 beta,16 beta-triol (3), 24-methylenecycloartane-3 beta,7 beta,16 beta-triol 3-O-beta-D-xylopyranoside (4), 24-methylenecycloartane-3 beta,6 beta,16 beta-triol 3-O-beta-D-xylopyranoside (5), and 24-methylenecycloartane-3 beta,6 beta,7 beta-triol 3-O-beta-D-xylopyranoside (6), were isolated from the leaves of Homonoia riparia, together with one known compound, 24-methylenecycloartarie-3 beta,6 beta,7 beta,16 beta-tetraol 3-O-beta-D-xylopyranoside (7). The structures of the new triterpenes were established by spectroscopic studies and from chemical evidence, and the inhibitory effects of compounds 1 and 3-7 on VEGF-induced vascular permeability were examined in vivo in rats using the Miles assay. In addition, the inhibitory effect of 7 on VEGF-induced tube formation by HUVECs in vitro was investigated.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - 바이오나노대학 > 생명과학과 > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/16313)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.