Mutated IDH1 Is a Favorable Prognostic Factor for Type 2 Gliomatosis Cerebri
- Authors
- Kwon, Mi Jung; Kim, Sung Tae; Kwon, Mi Jeong; Kong, Doo-Sik; Lee, Dageun; Park, Sanghui; Kang, So Young; Song, Ji-Young; Nam, Do-Hyun; Kato, Yukinari; Choi, Yoon-La; Suh, Yeon-Lim
- Issue Date
- May-2012
- Publisher
- WILEY
- Keywords
- gliomatosis cerebri; IDH1; IDH2; mutations; prognostic factor
- Citation
- BRAIN PATHOLOGY, v.22, no.3, pp.307 - 317
- Journal Title
- BRAIN PATHOLOGY
- Volume
- 22
- Number
- 3
- Start Page
- 307
- End Page
- 317
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/16407
- DOI
- 10.1111/j.1750-3639.2011.00532.x
- ISSN
- 1015-6305
- Abstract
- The prognostic significance of IDH1 mutations has been demonstrated in gliomas. It is unclear whether IDH1 mutation is also a prognostic factor in gliomatosis cerebri (GC). Primary GCs can be grouped into type 1 GCs, which have the classical diffuse growth pattern without mass formation, and type 2 GCs, which form neoplastic masses in addition to classic diffuse lesions. In this study, the prognostic relevance of IDH1/2 mutations in 74 GCs (43 type 1 and 31 type 2) was evaluated. We detected 33 (44.6%) IDH1 mutations, including R132H and R132S, by bidirectional Sanger sequencing. No mutations were detected in IDH2. The percentage of 2-year overall survival for wild-type IDH1 patients was 46 vs. 72% for patients with IDH1-mutated tumors. Mutations of IDH1 were strongly correlated with both increased overall survival (OS) and progression-free survival (PFS) in patients with type 2 GCs, and IDH1 mutations were also an independent prognostic factor predicting increased OS and PFS in type 2 GC patients in multivariate analysis. However, IDH1 mutations did not correlate with survival outcomes in patients with type 1 GCs. Finally, the subgroup of GC, which has IDH1 wild-type and additional solid component showed the worst prognosis.
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