Increase in Insulin Secretion Induced by Panax ginseng Berry Extracts Contributes to the Amelioration of Hyperglycemia in Streptozotocin-induced Diabetic Mice
- Authors
- Park, Eun-Young; Kim, Ha-Jung; Kim, Yong-Kyoung; Park, Sang-Un; Choi, Jae-Eul; Cha, Ji-Young; Jun, Hee-Sook
- Issue Date
- Apr-2012
- Publisher
- KOREAN SOC GINSENG
- Keywords
- Panax ginsneg; Red ginseng berry; Green ginseng berry; Diabetes; Beta-cell proliferation
- Citation
- JOURNAL OF GINSENG RESEARCH, v.36, no.2, pp.153 - 160
- Journal Title
- JOURNAL OF GINSENG RESEARCH
- Volume
- 36
- Number
- 2
- Start Page
- 153
- End Page
- 160
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/16464
- DOI
- 10.5142/jgr.2012.36.2.153
- ISSN
- 1226-8453
- Abstract
- Panax-ginseng has long been used as a traditional herbal medicine. More recently, it has received attention for its anti-diabetic and anti-obesity effects in humans and in animal models of type 2 diabetes. In the present study, we tested the hypoglycemic effects of ginseng berry extract in beta-cell-deficient mice and investigated the mechanisms involved. Red (ripe) and green (unripe) berry extracts were prepared and administered orally (100 or 200 mg/kg body weight) to streptozotocin-induced diabetic mice daily for 10 wk. The body weight was measured daily, and the nonfasting blood glucose levels were measured after 5 and 10 wk after administration. Glucose tolerance tests were performed, and the serum insulin levels were measured. The proliferation of beta-cells was measured in vitro. The administration of red or green ginseng berry extract significantly reduced the blood glucose levels and improved the glucose tolerance in beta-cell deficient mice, with the higher doses resulting in better effects. Glucose-stimulated insulin secretion was significantly increased in berry extract-treated mice compared with streptozotocin-induced diabetic control mice. Treatment with ginseng berry extract increased beta-cell proliferation in vitro. Both red berry and green berry extracts improved glycemic control in streptozotocin-induced diabetic mice and increased insulin secretion, possibly due to increased beta-cell proliferation. These results suggest that ginseng berry extracts might have beneficial effects on beta-cell regeneration.
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