A Case of B-cell Lymphoma, Unclassifiable, with Features Intermediate between Diffuse Large B-cell Lymphoma and Burkitt Lymphoma in a Korean Child
- Authors
- Ahn, Jeong Yeal; Seo, Yiel Hea; Park, Pil Whan; Kim, Kyung Hee; Park, Mi Jung; Jeong, Ji Hoon; Park, Soon Ho; Song, Young Hee
- Issue Date
- Mar-2012
- Publisher
- KOREAN SOC LABORATORY MEDICINE
- Keywords
- Diffuse large B-cell lymphoma; Burkitt lymphoma; Gray zone lymphoma
- Citation
- ANNALS OF LABORATORY MEDICINE, v.32, no.2, pp.162 - 166
- Journal Title
- ANNALS OF LABORATORY MEDICINE
- Volume
- 32
- Number
- 2
- Start Page
- 162
- End Page
- 166
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/16555
- DOI
- 10.3343/alm.2012.32.2.162
- ISSN
- 2234-3806
- Abstract
- B-cell lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma (DLBCL) and Burkitt lymphoma (BL) (intermediate DLBCL/BL), is a heterogeneous group with some features resembling DLBCL and others resembling BL. Here, we report a case of intermediate DLBCL/BL in a Korean child. A 2-yr-old male was admitted for evaluation and management of left hip pain. Immunohistochemistry of a biopsy of the femur neck revealed tumor cells positive for CD20, CD10, BCL2, BCL6, and Ki67. A bone marrow (BM) aspirate smear revealed that 49.3% of all nucleated cells were abnormal lymphoid cells, composed of large- and medium-sized cells. Immunophenotyping of the neoplastic cells revealed positivity for CD19, CD10, CD20, and slg lambda and negativity for CD34, Tdt, and myeloperoxidase (MPO). Cytogenetic and FISH analyses showed a complex karyotype, including t(8;14)(q24.1;q32) and IGH-MYC fusion. Intensive chemotherapy was initiated, including prednisone, vincristine, L-asparaginase, daunorubicin, and central nervous system prophylaxis with intrathecal methotrexate (MTX) and cytarabine. One month after the initial diagnosis, BM examination revealed the persistent of abnormal lymphoid cells; cerebrospinal fluid cytology, including cytospin, showed atypical lymphoid cells. The patient was treated again with cyclophosphamide, vincristine, prednisone, adriamycin, MTX, and intrathecal MTX and cytarabine. The patient died of sepsis 5 months after the second round of chemotherapy.
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