Fractional exhaled nitric oxide and forced expiratory flow between 25% and 75% of vital capacity in children with controlled asthma
- Authors
- Yoon, J.-Y.; Woo, S.-I.; Kim, H.; Sun, Y.-H.; Hahn, Y.-S.
- Issue Date
- Sep-2012
- Publisher
- Korean Pediatric Society
- Keywords
- Asthma; Child; Inhaled corticosteroids; Nitric oxide; Spirometry
- Citation
- Korean Journal of Pediatrics, v.55, no.9, pp.372 - 379
- Journal Title
- Korean Journal of Pediatrics
- Volume
- 55
- Number
- 9
- Start Page
- 372
- End Page
- 379
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/16683
- DOI
- 10.3345/kjp.2012.55.9.380
- ISSN
- 1738-1061
- Abstract
- Purpose: Fractional exhaled nitric oxide (FeNO) and forced expiratory flow between 25% and 75% of vital capacity (FEF25-75) are not included in routine monitoring of asthma control. We observed changes in FeNO level and FEF2S-7S after FeNO-based treatment with inhaled corticosteroid (ICS) in children with controlled asthma (CA). Methods: We recruited 148 children with asthma (age, 8 to 16 years) who had maintained asthma control and normal forced expiratory volume in the first second (FEV1) without control medication for >3 months. Patients with FeNO levels >25 ppb were allocated to the ICS- treated (FeNO-based management) or untreated group (guideline-based management). Changes in spirometric values and FeNO levels from baseline were evaluated after 6 weeks. Results: Ninety-three patients had FeNO levels >25 ppb. These patients had lower FEF25-75% predicted values than those with FeNO levels <25 ppb (P<0.01). After 6 weeks, the geometric mean (GM) FeNO level in the ICS-treated group was 45% lower than the baseline value, and the mean percent increase in FEF25-75 was 18.7% which was greater than that in other spirometric values. There was a negative correlation between percent changes in FEF25-75 and FeNO (r=-0.368, P=0.001). In contrast, the GM FeNO and spirometric values were not significantly different from the baseline values in the untreated group. Conclusion: The anti-inflammatory treatment simultaneously improved the FeNO levels and FEF25-75 in CA patients when their FeNO levels were >25 ppb. © 2012 by The Korean Pediatric Society.
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