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Wogonin이 polyinosinic-polycytidylic acid로 유발된 인간 신경모세포종 SH-SY5Y의 hydrogen peroxide 생성증가에 미치는 영향Effect of Wogonin on Hydrogen Peroxide Production in Polyinosinic-Polycytidylic acid-induced Human Neuroblastoma SH-SY5Y Cells
- Other Titles
- Effect of Wogonin on Hydrogen Peroxide Production in Polyinosinic-Polycytidylic acid-induced Human Neuroblastoma SH-SY5Y Cells
- Authors
- 박완수
- Issue Date
- 2012
- Publisher
- 한의병리학회
- Keywords
- Wogonin; Neuronal cells; DsRNA; Hydrogen peroxide; Anti-oxidative
- Citation
- 동의생리병리학회지, v.26, no.4, pp.491 - 496
- Journal Title
- 동의생리병리학회지
- Volume
- 26
- Number
- 4
- Start Page
- 491
- End Page
- 496
- ISSN
- 1738-7698
- Abstract
- The purpose of this study is to investigate the modulatory effect of wogonin on hydrogen peroxide production in human blastoma SH-SY5Y cells induced by the synthetic analog of double-stranded RNA [polyinosinic-polycytidylic acid]. Hydrogen peroxide production was measured by dihydrorhodamine 123 (DHR) assay. Wogonin significantly inhibited the polyinosinic-polycytidylic acid (PIC)-induced production of hydrogen peroxide for 0.5, 2, 12, 18, and 24 hr incubation at the concentrations of 10, 25, and 50 μM in SH-SY5Y (P < 0.05) in dose dependent manner. These results suggest that wogonin has neuroprotective property related with its inhibition of hydrogen peroxide production in PIC-induced neuronal cells.
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Related Researcher
- Park, Wan Su
- College of Korean Medicine (Premedical course of Oriental Medicine)