丹蔘이 뇌조직출혈 흰쥐의 신경세포 자연사에 미치는 영향Effects of Salvia Miltriorrhiza Radix on Neuronal Apoptosis following Intracerebral Hemorrhage of Rats
- Other Titles
- Effects of Salvia Miltriorrhiza Radix on Neuronal Apoptosis following Intracerebral Hemorrhage of Rats
- Authors
- 이흥기; 김연섭
- Issue Date
- 2012
- Publisher
- 대한본초학회
- Keywords
- Salvia Miltriorrhiza Radix(SMR); Collagenase; TUNEL; Bax; Bcl-2
- Citation
- 대한본초학회지, v.27, no.3, pp.89 - 94
- Journal Title
- 대한본초학회지
- Volume
- 27
- Number
- 3
- Start Page
- 89
- End Page
- 94
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/17363
- ISSN
- 1229-1765
- Abstract
- Objects : The purpose of this study was to observe the effect of Salviae Miltriorrhiza Radix(SMR) water-extract on intracerebral hemorrhage(ICH) and neuronal apoptosis in the injured areas.
Method : ICH was induced by the stereotaxic intrastriatal injection of bacterial collagenase type IV in Sprague-Dawley rats. The rats were givened oral SMR treatment once a day for three days after the ICH treatment. TUNEL positive cells in the affected regions were performed by TUNEL assay, Bax and Bcl-2 positive cells by immunohistochemistry and the Bax expression by western blotting method.
Results : The results are as follow;1. SMR significantly reduced the number of TUNEL positive cells in the peri-hematoma reigions of ICH-induced rats.
2. SMR significantly reduced the number of Bax positive cells in the peri-hematoma regions of ICH-induced rats.
3. SMR did not affect the number of Bcl-2 positive cells in the peri-hematoma regions of ICH-induced rats.
4. SMR significantly reduced the Bax expressions compared with ICH group in hemorrhagic hemisphere of ICH-induced rats.
Conclusion : These results suggest that SMR is effective in reducing neuronal apoptosis.
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