Asian Dust Particles Induce TGF-β1 via Reactive Oxygen Species in Bronchial Epithelial Cells
- Authors
- Kyung, Sunyoung; Yoon, Jin Young; Kim, Yu Jin; Lee, Sang Pyo; Park, Jeong-Woong; Jeong, Sung Hwan
- Issue Date
- Aug-2012
- Publisher
- 대한결핵및호흡기학회
- Keywords
- Air pollutants; Reactive oxygen species; Transforming growth factor β
- Citation
- Tuberculosis and Respiratory Diseases, v.73, no.2, pp.84 - 92
- Journal Title
- Tuberculosis and Respiratory Diseases
- Volume
- 73
- Number
- 2
- Start Page
- 84
- End Page
- 92
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/17464
- DOI
- 10.4046/trd.2012.73.2.84
- ISSN
- 1738-3536
- Abstract
- Background: Asian dust storms can be transported across eastern Asia. In vitro, Asian dust particle-induced inflammation and enhancement of the allergic reaction have been observed. However, the fibrotic effects of Asian dust particles are not clear. Production of transforming growth factor β 1 (TGF-β 1) and fibronectin were investigated in the bronchial epithelial cells after exposure to Asian dust particulate matter (AD-PM10). Methods: During Asian dust storm periods, air samples were collected. The bronchial epithelial cells were exposed to AD-PM10 with and without the antioxidant, N-acetyl-L-cysteine (NAC). Then TGF-β 1 and fibronectin were detected by Western blotting. The reactive oxygen species (ROS) was detected by the measurement of dicholorodihydrofluorescin (DCF), using a FACScan, and visualized by a confocal microscopy. Results: The expression of TGF-β 1, fibronectin and ROS was high after being exposed to AD-PM10, compared to the control. NAC attenuated both TGF-β 1 and fibronectin expression in the AD-PM10-exposed the bronchial epithelial cells. Conclusion: AD-PM10 may have fibrotic potential in the bronchial epithelial cells and the possible mechanism is AD-PM10-induced intracellular ROS. Copyright©2012. The Korean Academy of Tuberculosis and Respiratory Diseases. All rights reserved.
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