A genome-wide single-nucleotide polymorphism-array can improve the prognostic stratification of the core binding factor acute myeloid leukemia
- Authors
- Huh, J.; Kim, H.; Jung, C.W.; Kim, H.; Kim, S.-H.; Kim, Y.-K.; Kim, H.; Shin, M.G.; Moon, J.H.; Sohn, S.K.; Kim, S.H.; Lee, W.S.; Won, J.H.; Mun, Y.C.; Kim, H.; Park, J.; Min, W.S.; Kim, D.H.
- Issue Date
- Oct-2012
- Publisher
- WILEY-BLACKWELL
- Citation
- American Journal of Hematology, v.87, no.10, pp.961 - 968
- Journal Title
- American Journal of Hematology
- Volume
- 87
- Number
- 10
- Start Page
- 961
- End Page
- 968
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/17477
- DOI
- 10.1002/ajh.23281
- ISSN
- 0361-8609
- Abstract
- Core binding factor (CBF) AML with the D816 C-KIT gene mutation demonstrate inferior treatment outcomes. However, the remaining cases without the D816 C-KIT mutation imply a requirement of more sophisticated dissection of the patients according to their prognosis. In this study, we analyzed the prognostic value of a single nucleotide polymorphism array (SNP-A) based karyotyping combined with metaphase cytogenetics (MC) to facilitate further stratification of CBF AML patients. A total of 98 CBF AML patients were included and genome-wide Human SNP 6.0 Arrays (Affymetrix) were performed using marrow samples taken at diagnosis. Overall, 40 abnormal lesions were identified in 25 patients (26%). Survival of the patients with the abnormal lesion(s) detected by SNP-A and/or MC was worse than those without lesions in terms of the 2-year overall survival (OS; 57.5% vs. 76.4%, P = 0.028), event-free (EFS; 45.7% vs. 66.2%, P = 0.072), and leukemia-free survival (LFS; 49.0% vs. 77.4%, P = 0.015), specially in the subgroup with inv(16)/t(16;16) (40.9% vs. 80.2% OS, P = 0.040) and in the subgroup without the D816 C-KIT mutation (61.6% vs. 82.7% OS, P = 0.038). Multivariate analysis confirmed the prognostic impact of the abnormal SNP-A and/or MC lesion on EFS (HR 2.011, P = 0.047), and LFS (HR 3.231, P = 0.005) in the overall CBF AML. This study suggests that the combined use of SNP-A with MC in the CBF AML can provide important prognostic value, especially in the inv(16)/t(16;16) subgroup or in the patients without the D816 C-KIT mutation. © 2012 Wiley Periodicals, Inc.
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