Development of Botulinum Toxin A-Coated Microneedles for Treating Palmar Hyperhidrosis
- Authors
- Shim, Doo Hee; Thuy Trang Tguyen; Park, Pil-gu; Kim, Min Jung; Park, Byung-Wook; Jeong, Hye-Rin; Kim, Dae-Sung; Joo, Hyun Woo; Choi, Seong-O; Park, Jung-Hwan; Lee, Jae Myun
- Issue Date
- Dec-2019
- Publisher
- AMER CHEMICAL SOC
- Keywords
- microneedles; botulinum toxin A; hyperhidrosis
- Citation
- MOLECULAR PHARMACEUTICS, v.16, no.12, pp.4913 - 4919
- Journal Title
- MOLECULAR PHARMACEUTICS
- Volume
- 16
- Number
- 12
- Start Page
- 4913
- End Page
- 4919
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/17899
- DOI
- 10.1021/acs.molpharmaceut.9b00794
- ISSN
- 1543-8384
- Abstract
- Hyperhidrosis is a disorder that is characterized by the production of excess amounts of sweat. The botulinum neurotoxin A (BoNT/A) has been used to treat hyperhidrosis through multiple intradermal injections at the site of the condition. However, because of BoNT/A toxicity, it is important to precisely deliver the proper dose of the toxin to the target site. In addition, the use of a conventional hypodermic needle for multiple injections in the palm makes the approach undesirable and painful. Here, we designed a BoNT/A-coated microneedle (BoNT-MN) array and tested its efficacy as a substitute pain free method to treat hyperhidrosis. BoNT-MNs were prepared by coating polylactic acid microneedles with a BoNT/A formulation and were found to successfully penetrate into a thick skin in vitro. The coating formulations were then tested for their stability at 4, 25, and 37 degrees C for 24 h. BoNT-MNs were found to be much more stable than BoNT/A in a liquid state. Additionally, we carried out in vivo experiments by treating the right paws of mice with BoNT-MNs and found that the treatment induced a significant reduction in the sweating response in the mouse foot pad. Thus, BoNT/A treatment using microneedles is beneficial and may be used as a more efficient and less painful approach to treat hyperhidrosis.
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