VITAMIN D DEFICIENCY AND NEUROLOGIC OUTCOME AFTER SUDDEN CARDIAC ARREST
- Authors
- Cha, Jung-Joon; Wi, Jin
- Issue Date
- Dec-2019
- Publisher
- LIPPINCOTT WILLIAMS & WILKINS
- Keywords
- Cerebral performance category; resuscitation; sudden cardiac arrest; vitamin D deficiency
- Citation
- SHOCK, v.52, no.6, pp.E146 - E152
- Journal Title
- SHOCK
- Volume
- 52
- Number
- 6
- Start Page
- E146
- End Page
- E152
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/17945
- DOI
- 10.1097/SHK.0000000000001335
- ISSN
- 1073-2322
- Abstract
- Background: Vitamin D deficiency is related to various cardiovascular diseases, including sudden cardiac arrest (SCA). This study investigated the association of vitamin D level with neurologic outcome and mortality after resuscitation from SCA. Patients and Methods: We enrolled patients who were successfully resuscitated from out-of-hospital cardiac arrest of presumed cardiac cause in Severance Cardiovascular Hospital as a prospective cohort registry. Baseline blood samples including pH, lactate, and vitamin D were obtained without fluid replacement just after hospital admission. Outcome was assessed by cerebral performance category (CPC) score at 1 month after SCA. Favorable outcome was defined as survival with CPC score of 1 or 2, whereas unfavorable one as death or survival with CPC scores of 3 through 5. Severe vitamin D deficiency was defined as 25(OH)D <10 ng/mL. Results: A total of 163 patients were included. Overall 96 (59%) patients had a favorable neurologic outcome, whereas 67 patients (41%) showed unfavorable outcome, including 37 (23%) mortality. Patients with unfavorable outcome were likely to be female and have initial non-shockable rhythm, longer arrest time, severe shock, diabetes, and baseline renal dysfunction. In multivariate analysis, severe vitamin D deficiency was one of the poor prognostic factors of both unfavorable neurologic outcome and mortality after SCA. Conclusions: Vitamin D deficiency is very prevalent and strongly associated with both unfavorable neurologic outcome and mortality in patients resuscitated from SCA.
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