Mitoxantrone-Loaded PEGylated Gold Nanocomplexes for Cancer Therapy
- Authors
- Yoon, Jin-Ha; Cho, Hyun-Jong; Jin, Hyo-Eon; Maeng, Han-Joo
- Issue Date
- Feb-2019
- Publisher
- AMER SCIENTIFIC PUBLISHERS
- Keywords
- Mitoxantrone; Gold Nanoparticle; Polyethylene Glycol; Stability; Loading Efficiency
- Citation
- JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY, v.19, no.2, pp.687 - 690
- Journal Title
- JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
- Volume
- 19
- Number
- 2
- Start Page
- 687
- End Page
- 690
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/1866
- DOI
- 10.1166/jnn.2019.15902
- ISSN
- 1533-4880
- Abstract
- Gold nanoparticles (AuNPs) have been widely used as drug delivery carriers for cancer targeting and therapy. In this study, we developed mitoxantrone (MX)-loaded poly(ethylene glycol)-modified AuNPs complexes (AuNPs-PEG-MX) and evaluated its physicochemical properties compared to AuNPs, free MX, and MX-loaded AuNPs (AuNPs-MX). The results of surface plasmon resonance (SPR) measurement provided corresponded characteristics of free MX and AuNP groups, which determined by electrophoretic light scattering (ELS) method. The hydrodynamic size of AuNPsPEG-MX was lower than that of AuNPs-MX. Furthermore, loading efficiency of AuNPs-PEG-MX was 1.9-fold increased than AuNPs-MX. In addition, AuNPs-PEG-MX showed similar cytotoxicity compared to AuNPs-MX group in HeLa cells with enhanced drug release. Conclusively, AuNPsPEG-MX could be applied for in vivo cancer therapy via passive targeting based on the enhanced permeability and retention effect after intravenous injection.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - 약학대학 > 약학과 > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/1866)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.