Detailed Information
Cited 10 time in 
Cited 12 time in 
Cited 12 time in
Metadata Downloads
Synthesis and anti-neuroinflammatory activity of N-heterocyclic analogs based on natural biphenyl-neolignan honokiol
- Issue Date
- 15-Jan-2019
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Keywords
- Honokiol; Biphenyl-neolignan; Isoxazole; Pyrazole; Anti-neuroinflammatory activity
- Citation
- BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.29, no.2, pp.329 - 333
- Journal Title
- BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Volume
- 29
- Number
- 2
- Start Page
- 329
- End Page
- 333
- ISSN
- 0960-894X
- Abstract
- Novel isoxazole and pyrazole analogs based on natural biphenyl-neolignan honokiol were synthesized and evaluated for their inhibitory activities against nitric oxide production in lipopolysaccharide-activated BV-2 microglial cells. The isoxazole skeleton was constructed via nitrile oxide cycloaddition from oxime 3 and pyrazole was generated by condensation of 4-chromone and alkylhydrazine. Among the analogs, 13b and 14a showed stronger inhibitory activities with IC50 values of 8.9 and 1.2 mu M, respectively, than honokiol.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - 약학대학 > 약학과 > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
Related Researcher
- Kim, Sun Yeou
- Pharmacy (Dept.of Pharmacy)