Expression of UTX Indicates Poor Prognosis in Patients with Luminal Breast Cancer and is Associated with MMP-11 Expression
- Authors
- Kim, G.J.; Kim, D.-H.; Min, K.-W.; Chae, S.W.; Kim, S.H.; Son, B.K.; Moon, K.M.; Kim, Y.H.
- Issue Date
- Aug-2020
- Publisher
- Lippincott Williams and Wilkins
- Keywords
- Breast cancer; MMP-11; molecular classification; prognosis; UTX
- Citation
- Applied Immunohistochemistry and Molecular Morphology, v.28, no.7, pp.544 - 550
- Journal Title
- Applied Immunohistochemistry and Molecular Morphology
- Volume
- 28
- Number
- 7
- Start Page
- 544
- End Page
- 550
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/2064
- DOI
- 10.1097/PAI.0000000000000795
- ISSN
- 1541-2016
- Abstract
- Ubiquitously transcribed tetratricopeptide repeat, X chromosome (UTX) is involved in the epigenetic regulation. A previous mouse xenograft study revealed that UTX knockdown is associated with downregulated expression of matrix metalloproteinase-11 (MMP-11). The authors investigated 224 cases of breast cancer from Kangbuk Samsung Medical Center between 2000 and 2005. Nuclear UTX and cytoplasmic MMP-11 expressions were assessed using immunohistochemistry of tumor tissue microarray specimens. The relationships between the expression of UTX, MMP-11, and patients' outcomes were analyzed. UTX expression was significantly associated with high histologic grade, lymphatic invasion, vascular invasion, and tumoral expression of MMP-11. Survival analysis revealed that patients with UTX expression had a poorer overall survival rate (P= 0.010) as well as diminished disease-free survival rate (P= 0.001). The prognostic power of UTX expression was significant in patients with luminal-type breast cancer (P=0.027, overall survival; P=0.008, disease-free survival). Validation of UTX can provide further prognostic information beyond traditional indicators and represents a potential therapeutic target for breast cancer. © 2019 Wolters Kluwer Health, Inc. All rights reserved.
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