In vivo screening of herbal extracts on high Glucose-induced changes in Hyaloid-retinal vessels of zebrafish고혈당으로 유도된 제브라피쉬 당뇨망막병증 모델에서 약용식물의 효능 평가
- Other Titles
- 고혈당으로 유도된 제브라피쉬 당뇨망막병증 모델에서 약용식물의 효능 평가
- Authors
- 이유리; 정승현; 이익수; 김주환; 김영숙; 김진숙
- Issue Date
- Apr-2019
- Publisher
- Korean Society of Pharmacognosy
- Keywords
- Diabetic complications; Diabetic retinopathy; Herbal medicines; Zebrafish
- Citation
- Korean Journal of Pharmacognosy, v.50, no.1, pp.25 - 31
- Journal Title
- Korean Journal of Pharmacognosy
- Volume
- 50
- Number
- 1
- Start Page
- 25
- End Page
- 31
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/2092
- ISSN
- 0253-3073
- Abstract
- The zebrafish (Danio rerio) is an established model organism for several pathophysiological conditions which are related to human diseases. In this study, we tested the preventive effect of eight herbal extracts, which show the inhibitory effect of advanced glycation end products (AGEs) or aldose reductase (AR) in our previous study, on high glucose (HG)-induced retinal vessel dilation in larval zebrafish and analyzed the change of hyaloid vasculature. HG-induced zebrafish hyaloid vasculatures were significantly increased in the thickness compared to untreated zebrafish (P<0.001, n=6~10). Eight herbal extracts were found to have significant retinal vessel dilation on the inhibitory activity. Particularly, Brandisia hancei (twigs and fruits), Castanopsis orthacantha (leaves and twigs), Litsea japonica (leaves and twigs), Spenceria ramalana (whole plant), and Synedrella nodiflora (leaves and stems) showed potent inhibitory activity against retinal vessel dilation in HG-induced larval zebrafish. © 2019 Korean Journal of Pharmacognosy. All rights reserved.
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