Mitigation effects of red Platycodon grandiflorum extract on lipopolysaccharide-induced inflammation in splenocytes isolated from mice*
- Authors
- Park, E.-J.; Lee, Y.-S.; Jeong, H.C.; Lee, S.-H.; Lee, H.-J.
- Issue Date
- Jun-2019
- Publisher
- Korean Nutrition Society
- Keywords
- Anti-inflammatory; Platycodon grandiflorum; Splenocytes
- Citation
- Journal of Nutrition and Health, v.52, no.3, pp.243 - 249
- Journal Title
- Journal of Nutrition and Health
- Volume
- 52
- Number
- 3
- Start Page
- 243
- End Page
- 249
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/2109
- DOI
- 10.4163/jnh.2019.52.3.243
- ISSN
- 2288-3886
- Abstract
- Purpose: Platycodon grandiflorum (PG) is known to have effective antimicrobial and anticancer activity. The main bioactive components of PG are saponins, and these could contribute to anti-inflammatory activity. However, little is known about the anti-inflammatory effect of PG. In this study, we aim to assess the anti-inflammatory response to Red PG Extract (RPGE) in splenocytes under ex vivo conditions. Methods: The cell viability of isolated splenocytes taken from mice was analyzed by performing a Cell Counting Kit-8 assay. The productions of nitric oxide (NO) and cytokines (specifically interleukin-6 (IL-6) and interleukin-10 (IL-10)) were measured utilizing Griess reagent and ELISA, respectively. Results: We found that co-treatment with RPGE and Lipopolysaccharide (LPS) decreased isolated splenocyte proliferation as compared with that of the LPS-stimulated control. We also observed that RPGE markedly suppressed NO synthesis and IL-6 production that was induced by LPS. There were no significant differences of IL-10 production between co-treatment with RPGE plus LPS and treatment with LPS alone. Conclusion: When taken together, our data has shown that RPGE mitigates LPS-induced inflammation in splenocytes isolated from mice. Further research is surely needed to confirm the anti-inflammation effects of RPGE in an in vivo model. © 2019 The Korean Nutrition Society
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