Nitrilotriacetic acid-end-functionalized polycaprolactone as a template for polymer-protein nanocarriers
DC Field | Value | Language |
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dc.contributor.author | Jose, Leeja | - |
dc.contributor.author | Hwang, Aran | - |
dc.contributor.author | Lee, Chaeyeon | - |
dc.contributor.author | Shim, KyuHwan | - |
dc.contributor.author | Song, Jae Kwang | - |
dc.contributor.author | An, Seong Soo A. | - |
dc.contributor.author | Paik, Hyun-jong | - |
dc.date.available | 2020-04-06T06:37:15Z | - |
dc.date.created | 2020-04-02 | - |
dc.date.issued | 2020-03-07 | - |
dc.identifier.issn | 1759-9954 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/26078 | - |
dc.description.abstract | Diverse polymer-protein nanostructures were introduced as promising platforms for biomedical applications based on their unification of biocompatibility, the bespoke functionalities of proteins, and the structural integrity of polymers. Previously, the polymer-templated protein nanoball (PTPNB) system with Ni2+-nitrilotriacetic acid-end-functionalized polystyrene (Ni2+-NTA-PS) and His(6)-GFP was reported. These synthesized nanostructures maintained a high protein activity and protein orientation through a soft and strong specific Ni2+-NTA/histidine synergy between the protein and the polymer. However, the toxicity of polystyrene (PS) was a major limitation of the PTPNB system for biomedical applications. Herein, biocompatible polymer-protein nanocarriers were developed by synthesizing nickel-complexed nitrilotriacetic acid-end-functionalized polycaprolactone (Ni2+-NTA-PCL). The potentiality of the current system was the preparation of polymer-protein hybrid nanocarriers with the loaded doxorubicin (DOX) in a one-pot process. Finally, the capability of DOX-loaded GFP/PCL as a therapeutic vehicle was verified by the cellular internalization and cytotoxicity test with neuroblastoma SH-SY5Y cells. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ROYAL SOC CHEMISTRY | - |
dc.relation.isPartOf | POLYMER CHEMISTRY | - |
dc.subject | RESPONSIVE DRUG-DELIVERY | - |
dc.subject | CANCER-CELLS | - |
dc.subject | NANOPARTICLES | - |
dc.subject | PLGA | - |
dc.subject | IMMOBILIZATION | - |
dc.subject | LIGAND | - |
dc.subject | POLYSTYRENES | - |
dc.subject | SEPARATION | - |
dc.subject | SCAFFOLDS | - |
dc.subject | COPOLYMER | - |
dc.title | Nitrilotriacetic acid-end-functionalized polycaprolactone as a template for polymer-protein nanocarriers | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000518640400003 | - |
dc.identifier.doi | 10.1039/c9py01663e | - |
dc.identifier.bibliographicCitation | POLYMER CHEMISTRY, v.11, no.9, pp.1580 - 1588 | - |
dc.identifier.scopusid | 2-s2.0-85080902554 | - |
dc.citation.endPage | 1588 | - |
dc.citation.startPage | 1580 | - |
dc.citation.title | POLYMER CHEMISTRY | - |
dc.citation.volume | 11 | - |
dc.citation.number | 9 | - |
dc.contributor.affiliatedAuthor | An, Seong Soo A. | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | RESPONSIVE DRUG-DELIVERY | - |
dc.subject.keywordPlus | CANCER-CELLS | - |
dc.subject.keywordPlus | NANOPARTICLES | - |
dc.subject.keywordPlus | PLGA | - |
dc.subject.keywordPlus | IMMOBILIZATION | - |
dc.subject.keywordPlus | LIGAND | - |
dc.subject.keywordPlus | POLYSTYRENES | - |
dc.subject.keywordPlus | SEPARATION | - |
dc.subject.keywordPlus | SCAFFOLDS | - |
dc.subject.keywordPlus | COPOLYMER | - |
dc.relation.journalResearchArea | Polymer Science | - |
dc.relation.journalWebOfScienceCategory | Polymer Science | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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