Microneedle Array Patch (MAP) Consisting of Crosslinked Hyaluronic Acid Nanoparticles for Processability and Sustained Release
- Authors
- Kim, Dae-Sung; Choi, Jun-Tae; Kim, Cheong Bi; Shin, Yu-Ra; Park, Pil-Gu; Kim, Hyemi; Lee, Jae Myun; Park, Jung-Hwan
- Issue Date
- 7-Feb-2020
- Publisher
- SPRINGER/PLENUM PUBLISHERS
- Keywords
- crosslinked hyaluronic acid; microneedles; nanoparticles; processability; puncture performance; sustained release
- Citation
- PHARMACEUTICAL RESEARCH, v.37, no.3
- Journal Title
- PHARMACEUTICAL RESEARCH
- Volume
- 37
- Number
- 3
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/26099
- DOI
- 10.1007/s11095-020-2768-3
- ISSN
- 0724-8741
- Abstract
- Aims Crosslinked hyaluronic acid (X-linked HA) is not suitable for making microneedles because of the low fluidity of X-linked HA hydrogel. Microneedles were fabricated using X-linked HA nanoparticles (X-linked HA-NPs) to utilize the sustained drug delivery capability of X-linked HA-NPs and to obtain the processability advantages of X-linked HA. Method The puncture performance of a microneedle array patch (MAP) made of crosslinked hyaluronic acid nanoparticles (X-linked HA-NP-MAP) was evaluated by insertion in vitro into porcine skin. After a predetermined attachment time, the remaining height of the X-linked HA-NP-MAP was measured to determine the dissolution rate. X-linked HA-NP-MAP and free HA-MAP containing Rhodamine B isothiocyanate-dextran were administered into the back skin of mice, and the relative fluorescent intensity in the back skin was measured over time. Results The puncture performance of the X-linked HA-NP-MAP was over 90%. The diameter of redispersed X-linked HA-NPs was same as that of the premolded X-linked HA-NPs. The dissolution rate was not different from that of free HA-MAP. In an in vivo experiment, X-linked HA-NP-MAP was administered into the mouse's back skin successfully and the relative fluorescent intensity of X-linked HA-NP-MAP lasted longer than that of HA-MAP. Conclusion X-linked HA-NPs provide the biocompatibility, the processability of micromolding, sustained drug release, successful penetration into the skin, and relatively short insertion time for full disintegration of NPs in the skin. X-linked HA-NP-MAP can be used for various applications that require several days of sustained drug release.
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