Regulation of BDNF-TrkB Signaling and Potential Therapeutic Strategies for Parkinson's Disease
- Authors
- Jin, Wook
- Issue Date
- Jan-2020
- Publisher
- MDPI
- Keywords
- TrkB; Parkinson' s disease; BDNF; TrkB isoform; neuronal degeneration
- Citation
- JOURNAL OF CLINICAL MEDICINE, v.9, no.1
- Journal Title
- JOURNAL OF CLINICAL MEDICINE
- Volume
- 9
- Number
- 1
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/26177
- DOI
- 10.3390/jcm9010257
- ISSN
- 2077-0383
- Abstract
- Brain-derived neurotrophic factor (BDNF) and its receptor tropomyosin-related kinase receptor type B (TrkB) are widely distributed in multiple regions of the human brain. Specifically, BDNF/TrkB is highly expressed and activated in the dopaminergic neurons of the substantia nigra and plays a critical role in neurophysiological processes, including neuro-protection and maturation and maintenance of neurons. The activation as well as dysfunction of the BDNF-TrkB pathway are associated with neurodegenerative diseases. The expression of BDNF/TrkB in the substantia nigra is significantly reduced in Parkinson's Disease (PD) patients. This review summarizes recent progress in the understanding of the cellular and molecular roles of BNDF/TrkB signaling and its isoform, TrkB.T1, in Parkinson's disease. We have also discussed the effects of current therapies on BDNF/TrkB signaling in Parkinson's disease patients and the mechanisms underlying the mutation-mediated acquisition of resistance to therapies for Parkinson's disease.
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