防己茯苓湯이 백서에서 LPS로 유도된 우울증에서 면역 조직학적 변화에 미치는 효과Effect of Banggibongnyeongtang on the immunohistological change in LPS-induced depression rats
- Other Titles
- Effect of Banggibongnyeongtang on the immunohistological change in LPS-induced depression rats
- Authors
- 박성준; 이태희
- Issue Date
- Feb-2020
- Publisher
- 대한한의학방제학회
- Keywords
- banggibongnyeongtang; LPS; antidepression; 5-HT; IL-1β; TNF-α; BDNF
- Citation
- 대한한의학 방제학회지, v.28, no.1, pp.53 - 62
- Journal Title
- 대한한의학 방제학회지
- Volume
- 28
- Number
- 1
- Start Page
- 53
- End Page
- 62
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/26297
- ISSN
- 1229-1218
- Abstract
- Objective : This study is accomplished in order to investigate the effect of banggibongnyeongtang on the immunohistological change in LPS-induced depression rats to confirm the histological result of the previous behavioral and biochemical effect.
Methods : LPS 5 ㎍ was injected to lateral ventricle and experimental groups were administered BBT intraperitoneally. The concentration of 5-HT in the Medial Prefrontal Cortex, Striatum, Hippocampus, Amygdala was measured by ELISA. IL-1β, TNF-α mRNA and BDNF mRNA expression in the hippocampus was examined by RT-PCR.
Result : BBT enhanced 5-HT concentration at all part of brain but no significantly difference at medial prefrontal cortex and striatum. LPS+BBT400 group increased 5-HT concentration significantly than LPS group at hippocampus and amygdala (p<0.05). BBT decreased IL-1β mRNA expression dose dependently but only with significantly decrease in LPS+BBT400 group than LPS group’s in Hippocampus (p<0.05). But BBT did not decrease TNF-α mRNA expression significantly in Hippocampus. BBT increased the expression of BDNF mRNA at hippocampus and LPS+BBT400 group significantly increased comparing with LPS group does (p<0.05).
Conclusion : It is postulated that the anti-depressant effect of BBT can be validated through the anti-inflammatory effect, 5-HT concentration increase, and the neuro-protective effect mediated by BDNF by combining the results of the previous report about the behavioral and biochemical effect.
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