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Chemical constituents of Impatiens balsamina stems and their biological activities
- Authors
- Kim, D.H.; Lee, T.H.; Subedi, L.; Kim, S.Y.; Lee, K.R.
- Issue Date
- Jun-2019
- Publisher
- Korean Society of Pharmacognosy
- Keywords
- Balsaminaceae; Impatiens balsamina; Neuroprotective effect; Tetrahydronaphthalene
- Citation
- Natural Product Sciences, v.25, no.2, pp.130 - 135
- Journal Title
- Natural Product Sciences
- Volume
- 25
- Number
- 2
- Start Page
- 130
- End Page
- 135
- ISSN
- 1226-3907
- Abstract
- The purification of the MeOH extract from Impatiens basamina by repeated column chromatography led to the isolation of one new tetrahydronaphthalene (1), together with eleven known compounds (2-12). The structure of the new compound (1) was determined by spectral data analysis (1H and13C-NMR,1H-1H COSY, HSQC, HMBC, NOESY, and HR-ESI-MS). Isolated compounds (1-12) were evaluated for their inhibitory effects on NO production in LPS-activated murine microglial BV-2 cells and their effects on NGF secretion from C6 glioma cells. Compounds 3, 7, and 10 reduced NO levels in LPS-activated murine microglial cells with IC50 values of 26.89, 25.59, and 44.21 µM, respectively. Compounds 1, 5, and 9 upregulated NGF secretion to 153.09 ± 4.66, 156.88 ± 8.86, and 157.34 ± 3.30%, respectively. © 2019, Korean Society of Pharmacognosy. All rights reserved.
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Related Researcher
- Kim, Sun Yeou
- Pharmacy (Dept.of Pharmacy)