A Multidomain Intervention for Modifying Lifestyle Habits Reduces the Dementia Risk in Community-Dwelling Older Adults: A Single-Blinded Randomized Controlled Pilot Study
- Authors
- Park, Jee Eun; Jeon, So Yeon; Kim, Se An; Kim, Jin Ha; Kim, Seon Hwa; Lee, Kyung Won; Hwang, Yun Jung; Jung, Gijung; Suk, Hye Won; Park, Saejong; Lee, Dong Young
- Issue Date
- 2019
- Publisher
- IOS PRESS
- Keywords
- Aged; alzheimer' s disease; dementia; health promotion; risk reduction behavior
- Citation
- JOURNAL OF ALZHEIMERS DISEASE, v.70, no.1, pp.51 - 60
- Journal Title
- JOURNAL OF ALZHEIMERS DISEASE
- Volume
- 70
- Number
- 1
- Start Page
- 51
- End Page
- 60
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/2885
- DOI
- 10.3233/JAD-190016
- ISSN
- 1387-2877
- Abstract
- We aimed to examine the feasibility and effectiveness of a multidomain intervention including intensive and maintenance programs for reducing the risk of dementia in at-risk older adults. Community-dwelling older adults (aged >= 60 years) without dementia but having several risk factors for dementia (N = 32; 89% female; mean age f standard deviation, 76.8 +/- 4.7 years) were assigned to three parallel programs: intensive plus maintenance (INT+MNT), intensive only (INTonly), and active control. Subjects in INT+MNT and INT-only groups participated in a 4-week intensive group-based lifestyle modification program that focused on physical activity, vascular risk factors, dietary habits, cognitive activities, and social engagement. INT+MNT participants underwent an additional 20-week maintenance program to consolidate modified habits. The modified Australian National University-Alzheimer's Disease Risk Index (ANU-ADRI) score was used as the primary outcome measure for dementia risk. The changes in ANU-ADRI scores exhibited a significant group-by-time interaction: the INT+MNT group showed significant improvement at 24 weeks beta = -6.05; SE = 1.86; p= 0.002), while the INT-only group did not. Additional exploratory analyses showed that the reduction in ANU-ADRI scores was caused by changes in protective factors rather than in risk factors. The INT + MNT group also showed greater improvement in executive function at 4 and 24 weeks (both p = 0.044), whereas changes in global cognitive function did not reach significance (p = 0.055). A 24-week multidomain dementia prevention involving a maintenance strategy for sustaining modified lifestyle habits reduced the risk of dementia and improved executive function in at-risk older adults.
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