Hyperpolarized Porous Silicon Nanoparticles: Potential Theragnostic Material for Si-29 Magnetic Resonance Imaging
- Authors
- Seo, Hyeonglim; Choi, Ikjang; Whiting, Nicholas; Hu, Jingzhe; Luu, Quy Son; Pudakalakatti, Shivanand; McCowan, Caitlin; Kim, Yaewon; Zacharias, Niki; Lee, Seunghyun; Bhattacharya, Pratip; Lee, Youngbok
- Issue Date
- 5-Sep-2018
- Publisher
- WILEY-V C H VERLAG GMBH
- Keywords
- porous silicon nanoparticles; DNP; molecular magnetic resonance imaging; theragnostic material; Si-29 hyperpolarization
- Citation
- CHEMPHYSCHEM, v.19, no.17, pp.2143 - 2147
- Journal Title
- CHEMPHYSCHEM
- Volume
- 19
- Number
- 17
- Start Page
- 2143
- End Page
- 2147
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/3319
- DOI
- 10.1002/cphc.201800461
- ISSN
- 1439-4235
- Abstract
- Porous silicon nanoparticles have recently garnered attention as potentially-promising biomedical platforms for drug delivery and medical diagnostics. Here, we demonstrate porous silicon nanoparticles as contrast agents for Si-29 magnetic resonance imaging. Size-controlled porous silicon nanoparticles were synthesized by magnesiothermic reduction of silica nanoparticles and were surface activated for further functionalization. Particles were hyperpolarized via dynamic nuclear polarization to enhance their Si-29 MR signals; the particles demonstrated long Si-29 spin-lattice relaxation (T-1) times (approximate to 25mins), which suggests potential applicability for medical imaging. Furthermore, Si-29 hyperpolarization levels were sufficient to allow Si-29 MRI in phantoms. These results underscore the potential of porous silicon nanoparticles that, when combined with hyperpolarized magnetic resonance imaging, can be a powerful theragnostic deep tissue imaging platform to interrogate various biomolecular processes invivo.
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