Identification of bioactive heterocyclic compounds from mulberry and their protective effect against streptozotocin-induced apoptosis in INS-1 cells
- Authors
- Song, Ji Hoon; Lee, Dahae; Lee, Seoung Rak; Yu, Jae Sik; Jang, Tae Su; Nam, Joo-Won; Kim, Ki Hyun; Kang, Ki Sung
- Issue Date
- Apr-2018
- Publisher
- SPANDIDOS PUBL LTD
- Keywords
- Morus alba; streptozotocin; type 1 diabetes mellitus; reactive oxygen species
- Citation
- MOLECULAR MEDICINE REPORTS, v.17, no.4, pp.5982 - 5987
- Journal Title
- MOLECULAR MEDICINE REPORTS
- Volume
- 17
- Number
- 4
- Start Page
- 5982
- End Page
- 5987
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/3924
- DOI
- 10.3892/mmr.2018.8582
- ISSN
- 1791-2997
- Abstract
- A phytochemical investigation of the MeOH extracts from mulberries (the fruit of Morus alba L.) led to the identification of six heterocyclic compounds (1-6). These compounds were screened to detect whether they protected pancreatic INS-1 cells from streptozotocin (STZ)-induced cytotoxicity. Compound 3 was the most effective at preventing STZ-induced cytotoxicity and the production of reactive oxygen species (ROS) in INS-1 cells. In addition, compound 3 effectively prevented apoptosis induced by STZ in INS-1 cells. Compound 3 also prevented STZ-mediated cleavage of caspase-8, caspase-3 and poly (ADP-ribose) polymerase and increased the expression of B-cell lymphoma-2 (Bcl-2), an anti-apoptotic Bcl-2 family protein. In conclusion, the results of the present study indicate that compound 3 extracted from the fruit of M. alba was highly effective in preventing type 1 diabetes mellitus and may be a novel treatment option.
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