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Size-tunable protein-polymer hybrid carrier for cell internalization

Authors
Lee, ChaeyeonChoi, Ji EunPark, Gil YongLee, TaeheonKim, JinkuAn, Seong Soo A.Song, Jae KwangPaik, Hyun-jong
Issue Date
Mar-2018
Publisher
ELSEVIER SCIENCE BV
Keywords
Polymer-protein core-shell particle; Functional nanocarrier; One-pot method; Size-control; Endocytosis
Citation
REACTIVE & FUNCTIONAL POLYMERS, v.124, pp.72 - 76
Journal Title
REACTIVE & FUNCTIONAL POLYMERS
Volume
124
Start Page
72
End Page
76
URI
https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/4007
DOI
10.1016/j.reactfunctpolym.2018.01.006
ISSN
1381-5148
Abstract
We describe a polymer-templated protein nanoball (PTPNB) system as an in-situ platform for the preparation of polymer-protein core-shell capsules containing hydrophobic cargos. These structures boast high protein activity through soft immobilization and maintain a consistent protein orientation through a specific interaction between the protein and polymer. We demonstrate the potential of this PTPNB system through bio-conjugation, encapsulation, and size-control of nanoballs in a one-pot process, and furthermore characterize the effects of nanoball size on endocytosis.
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