Functional dissection of astrocyte-secreted proteins: Implications in brain health and diseases
- Authors
- Jha, Mithilesh Kumar; Kim, Jong-Heon; Song, Gyun Jee; Lee, Won-Ha; Lee, In-Kyu; Lee, Ho-Won; An, Seong Soo A.; Kim, SangYun; Suk, Kyoungho
- Issue Date
- Mar-2018
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Keywords
- Astrocyte; Secretory protein; Proteomics; Secretomics; Brain injury; Neurodegenerative disease; Neuroinflammation
- Citation
- PROGRESS IN NEUROBIOLOGY, v.162, pp.37 - 69
- Journal Title
- PROGRESS IN NEUROBIOLOGY
- Volume
- 162
- Start Page
- 37
- End Page
- 69
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/4011
- DOI
- 10.1016/j.pneurobio.2017.12.003
- ISSN
- 0301-0082
- Abstract
- Astrocytes, which are homeostatic cells of the central nervous system (CNS), display remarkable heterogeneity in their morphology and function. Besides their physical and metabolic support to neurons, astrocytes modulate the blood-brain barrier, regulate CNS synaptogenesis, guide axon pathfinding, maintain brain homeostasis, affect neuronal development and plasticity, and contribute to diverse neuropathologies via secreted proteins. The identification of astrocytic proteome and secretome profiles has provided new insights into the maintenance of neuronal health and survival, the pathogenesis of brain injury, and neurodegeneration. Recent advances in proteomics research have provided an excellent catalog of astrocyte-secreted proteins. This review categorizes astrocyte-secreted proteins and discusses evidence that astrocytes play a crucial role in neuronal activity and brain function. An in-depth understanding of astrocyte-secreted proteins and their pathways is pivotal for the development of novel strategies for restoring brain homeostasis, limiting brain injury/inflammation, counteracting neurodegeneration, and obtaining functional recovery. (c) 2017 Elsevier Ltd. All rights reserved.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - 바이오나노대학 > 바이오나노학과 > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/4011)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.