Antigastritis effects of Armillariella tabescens (Scop.) Sing. and the identification of its anti-inflammatory metabolites
- Authors
- Lee, Seulah; Lee, Dahae; Park, Jun Yeon; Seok, Soonja; Jang, Tae Su; Park, Hyun Bong; Shim, Sang Hee; Kang, Ki Sung; Kim, Ki Hyun
- Issue Date
- Mar-2018
- Publisher
- WILEY
- Keywords
- antigastritis; anti-inflammation; Armillariella tabescens; NF-kappa B; Tricholomataceae
- Citation
- JOURNAL OF PHARMACY AND PHARMACOLOGY, v.70, no.3, pp.404 - 412
- Journal Title
- JOURNAL OF PHARMACY AND PHARMACOLOGY
- Volume
- 70
- Number
- 3
- Start Page
- 404
- End Page
- 412
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/4022
- DOI
- 10.1111/jphp.12871
- ISSN
- 0022-3573
- Abstract
- ObjectivesThis study demonstrates the biological and chemical analysis of the mushroom Armillariella tabescens (Scop.) Sing. (Tricholomataceae). MethodsChemical structures of the isolates were determined by 1D and 2D NMR, and ESI-MS, as well as comparison with previously reported data. All isolates were tested for anti-inflammatory effects based on their ability to inhibit LPS-stimulated nitric oxide (NO) production in RAW264.7 cells. Key findingsWe found that the MeOH extract of the fruiting bodies of A. tabescens showed antigastritis activity against ethanol-induced gastric damage in rats and notably reduced the gastric damage index compared to control in a concentration-dependent manner. Chemical investigation of the MeOH extract led to the isolation of four steroids (1-4), three alkaloids (5-7), two nucleic acids (8-9) and four fatty acids (10-13). This is the first study to report the identification of all isolates, except for compound 7, from A. tabescens. Compounds 1, 2, 3, 4 and 10 showed inhibition on LPS-stimulated NO production. Treatment with compound 10 inhibited expression of iNOS, COX-2, phospho-IKK, IKK, phospho-IB, IB and NF-kappa B in LPS-stimulated RAW264.7 cells. ConclusionsCompound 10 likely contributes to the health benefits of A. tabescens as an antigastritis agent through its anti-inflammatory effects.
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