Chemical characterization of cytotoxic indole acetic acid derivative from mulberry fruit (Morus alba L.) against human cervical cancer
- Authors
- Yu, Jae Sik; Lee, Dahae; Lee, Seoung Rak; Lee, Jae Wook; Choi, Chang-Ik; Jang, Tae Su; Kang, Ki Sung; Kim, Ki Hyun
- Issue Date
- Feb-2018
- Publisher
- ACADEMIC PRESS INC ELSEVIER SCIENCE
- Keywords
- Mulberry; Morus alba; Indole acetic acid; Human cervical cancer
- Citation
- BIOORGANIC CHEMISTRY, v.76, pp.28 - 36
- Journal Title
- BIOORGANIC CHEMISTRY
- Volume
- 76
- Start Page
- 28
- End Page
- 36
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/4137
- DOI
- 10.1016/j.bioorg.2017.10.015
- ISSN
- 0045-2068
- Abstract
- The fruit of the white mulberry tree (Morus alba L.) is a multiple fruit with a sweet flavor commonly consumed around the world. Chemical investigation of the fruits led to the isolation of two indole acetic acid derivatives (1-2) including a new compound, which turned out to be an isolation artifact, 3S-(beta-D-gluco pyranosyloxy)-2,3-dihydro-2-oxo-1H-indole-3-acetic acid butyl ester (1), along with five known compounds (3-7). Compounds 2 and 7 were newly identified from mulberry fruit. The new isolation artifact (1) exhibited cytotoxic effect on human cervical cancer Hela cells in a dose-dependent manner. Compound 1 activated caspase-8, caspase-9, and caspase-3, followed by cleavage of PARP, a substrate of caspase-3, in a dose-dependent manner. Simultaneous alterations in protein expression of mitochondrial factors Bax, BID and Bcl-2 were also observed. A comparison between compounds 1 and 2 led to a structure-activity relationship analysis of the cytotoxic effect. These results suggest that compound 1 could be beneficial in human cervical cancer treatment, and provide a theoretical basis for further application of compound 1. (C) 2017 Elsevier Inc. All rights reserved.
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