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A New Diarylheptanoid from the Twigs of Quercus Acutissima and their Neuroprotective Activity
- Issue Date
- Mar-2020
- Publisher
- SPRINGER
- Keywords
- Quercus acutissima; Fagaceae; diarylheptanoid; neuroprotective effect; acutissioside A
- Citation
- CHEMISTRY OF NATURAL COMPOUNDS
- Journal Title
- CHEMISTRY OF NATURAL COMPOUNDS
- ISSN
- 0009-3130
- Abstract
- A new diarylheptanoid glycoside, acutissioside A (4), along with five known diarylheptanoids (1-3, 5, 6) was isolated from the twigs of Quercus acutissima Carruth. The structure of the new compound was determined via spectral analysis, including NMR spectra (H-1 and C-13 NMR, H-1-H-1 COSY, HSQC, HMBC) and HR-ESI-MS, acid hydrolysis, and specific optical rotation data. The neuroprotective effect of all the diarylheptanoid compounds (1-6) was evaluated. Compound 1 exhibited NGF secretion to 154.60 +/- 2.87%, which was stronger than that of the positive control 6-shogaol (140.45 +/- 2.18%).
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Collections - 약학대학 > 약학과 > 1. Journal Articles
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Related Researcher
- Kim, Sun Yeou
- Pharmacy (Dept.of Pharmacy)