Polysiphonia japonica Extract Attenuates Palmitate-Induced Toxicity and Enhances Insulin Secretion in Pancreatic Beta-Cells
- Authors
- Cha, Seon-Heui; Kim, Hyun-Soo; Hwang, Yongha; Jeon, You-Jin; Jun, Hee-Sook
- Issue Date
- Oct-2018
- Publisher
- HINDAWI LTD
- Citation
- OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, v.2018
- Journal Title
- OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
- Volume
- 2018
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/5278
- DOI
- 10.1155/2018/4973851
- ISSN
- 1942-0900
- Abstract
- Beta-cell loss is a major cause of the pathogenesis of diabetes. Elevated levels of free fatty acids may contribute to the loss of beta-cells. Using a transgenic zebrafish, we screened similar to 50 seaweed crude extracts to identify materials that protect beta-cells from free fatty acid damage. We found that an extract of the red seaweed Polysiphonia japonica (PJE) had a beta-cell protective effect. We examined the protective effect of PJE on palmitate-induced damage in beta-cells. PJE was found to preserve cell viability and glucose-induced insulin secretion in a pancreatic beta-cell line, Ins-1, treated with palmitate. Additionally, PJE prevented palmitate-induced insulin secretion dysfunction in zebrafish embryos and mouse primary islets and improved insulin secretion in beta-cells against palmitate treatment. These findings suggest that PJE protects pancreatic beta-cells from palmitate-induced damage. PJE may be a potential therapeutic functional food for diabetes.
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Collections - 약학대학 > 약학과 > 1. Journal Articles
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