Urinary and Blood MicroRNA-126 and-770 are Potential Noninvasive Biomarker Candidates for Diabetic Nephropathy: a Meta-Analysis
- Authors
- Park, Sungjin; Moon, SeongRyeol; Lee, Kiyoung; Park, Ie Byung; Lee, Dae Ho; Nam, Seungyoon
- Issue Date
- Apr-2018
- Publisher
- KARGER
- Keywords
- Diabetes mellitus; Diabetic nephropathy; MicroRNAs; Biomarkers
- Citation
- CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, v.46, no.4, pp.1331 - 1340
- Journal Title
- CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
- Volume
- 46
- Number
- 4
- Start Page
- 1331
- End Page
- 1340
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/5323
- DOI
- 10.1159/000489148
- ISSN
- 1015-8987
- Abstract
- Background/Aims: Diabetic nephropathy (DN), a major diabetic microvascular complication, has a long and growing list of biomarkers, including microRNA biomarkers, which have not been consistent across preclinical and clinical studies. This meta-analysis aims to identify significant blood- and urine-incident microRNAs as diagnostic/prognostic biomarker candidates for DN. Methods: PubMed, Web of Science, and Cochrane Library were searched from their earliest records through 12th Dec 2016. Relevant publications for the meta analysis included (1) human participants; (2) microRNAs in blood and urine; (3) DN studies; and (4) English language. Four reviewers, including two physicians, independently and blindly extracted published data regarding microRNA profiles in blood and/or urine from subjects with diabetic nephropathy. A random-effect model was used to pool the data. Statistical associations between diabetic nephropathy and urinary or blood microRNA expression levels were assessed. Results: Fourteen out of 327 studies (n=2,747 patients) were selected. Blood or urinary microRNA expression data of diabetic nephropathy were pooled for this analysis. The hsa-miR-126 family was significantly (OR: 0.57; 95% CI: 0.44-0.74; p-value < 0.0001) downregulated in blood from patients with diabetic kidney disease, while its urinary level was upregulated (OR: 2931.12; 95% CI: 9.96-862623.21; p-value = 0.0059). The hsa-mi R-770 family microRNA were significantly (OR: 10.24; 95% CI: 2.37-44.25; p-value = 0.0018) upregulated in both blood and urine from patients with diabetic nephropathy. Conclusions: Our meta analysis suggests that hsa-miR-126 and hsa-miR-770 family microRNA may have important diagnostic and pathogenetic implications for DN, which warrants further systematic clinical studies. (C) 2018 The Author(s) Published by S Karger AG, Basel.
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