Protective effect of casuarinin against glutamate-induced apoptosis in HT22 cells through inhibition of oxidative stress-mediated MAPK phosphorylation
- Authors
- Song, Ji Hoon; Kang, Ki Sung; Choi, You-Kyung
- Issue Date
- 1-Dec-2017
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Keywords
- Casuarinin; Glutamate; Reactive oxygen species; Mitogen-activated protein kinase; Apoptosis; HT22 cells
- Citation
- BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.27, no.23, pp.5109 - 5113
- Journal Title
- BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Volume
- 27
- Number
- 23
- Start Page
- 5109
- End Page
- 5113
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/5374
- DOI
- 10.1016/j.bmcl.2017.10.075
- ISSN
- 0960-894X
- Abstract
- Glutamate is the major excitatory neurotransmitter in the central nervous system and is involved in oxidative stress during neurodegeneration. In the present study, casuarinin prevented glutamate-induced HT22 murine hippocampal neuronal cell death by inhibiting intracellular reactive oxygen species (ROS) production. Moreover, casuarinin reduced chromatin condensation and annexin-V-positive cell production induced by glutamate. We also confirmed the underlying protective mechanism of casuarinin against glutamate-induced neurotoxicity. Glutamate markedly increased the phosphorylation of extracellular signal regulated kinase (ERK)-1/2 and p38, which are crucial in oxidative stress-mediated neuronal cell death. Conversely, treatment with casuarinin diminished the phosphorylation of ERK1/2 and P38. In conclusion, the results of this study suggest that casuarinin, obtained from natural products, acts as potent neuroprotective agent by suppressing glutamate-mediated apoptosis through the inhibition of ROS production and activation of the mitogen activated protein kinase (MAPK) pathway. Thus, casuarinin can be a potential therapeutic agent in the treatment of neurodegenerative diseases. (C) 2017 Elsevier Ltd. All rights reserved.
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