Administration of a Sol-Gel Formulation of Phenylephrine Using Low-Temperature Hollow Microneedle for Treatment of Intermittent Fecal Incontinence
- Authors
- Lee, Hyunji; Park, Jung-Hwan; Park, Jung Ho
- Issue Date
- Dec-2017
- Publisher
- SPRINGER/PLENUM PUBLISHERS
- Keywords
- intermittent occurrence offecal incontinence; local targeting; low pain; low temperature hollow microneedle; sol-gel formulation
- Citation
- PHARMACEUTICAL RESEARCH, v.34, no.12, pp.2809 - 2816
- Journal Title
- PHARMACEUTICAL RESEARCH
- Volume
- 34
- Number
- 12
- Start Page
- 2809
- End Page
- 2816
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/5429
- DOI
- 10.1007/s11095-017-2261-9
- ISSN
- 0724-8741
- Abstract
- A low temperature hollow microneedle system was devised to deliver sol-gel transition formulation near the surface of the skin for extended release and local delivery of drug by a non-invasive method. This new system can improve treatment of intermittent fecal incontinence. The low-temperature system was integrated with a hollow microneedle to maintain the low temperature of the sol formulation. Various sol-gel formulations using Pluronic F-127 (PF-127) and Hydroxy-propyl-methyl-cellulose (HPMC) were prepared, and their gelation temperature, flow property, and diffusion retardation were observed. Resting anal sphincter pressure in response to a phenylephrine (PE) sol-gel formulation was measured using an air-charged catheter. The biocompatibility of the sol-gel PE formulation was evaluated by observing the immunological response. When the PF-127 25%, HPMC 1% and PE formulation (PF25-HPMC1-PE) was injected through the peri-anal skin of the rat in vivo, the highest pressure on the anal sphincter muscle occurred at 6-8 h and anal pressure increased and lasted twice as long as with the phosphate-buffered saline (PBS)-PE formulation. There was no significant difference in the number of mast cells after administration into the rat in vivo between the PF25-HPMC1-PE formulation and the PBS-PE formulation. The combination of a low-pain hollow microneedle system and an injectable sol-gel formulation improved the efficacy of treatment of intermittent fecal incontinence. A low-temperature hollow microneedle system using a sol-gel formulation has many applications in medical treatments that require depot effect, local targeting, and pain control.
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Collections - 바이오나노대학 > 바이오나노학과 > 1. Journal Articles
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