The Role of Mammalian Target of Rapamycin (mTOR) in Insulin Signaling
- Authors
- Yoon, Mee-Sup
- Issue Date
- Nov-2017
- Publisher
- MDPI
- Keywords
- insulin; mammalian target of rapamycin (mTOR); mTOR complex1 (mTORC1); mTOR complex2 (mTORC2); protein kinase B (PKB; Akt)
- Citation
- NUTRIENTS, v.9, no.11
- Journal Title
- NUTRIENTS
- Volume
- 9
- Number
- 11
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/5494
- DOI
- 10.3390/nu9111176
- ISSN
- 2072-6643
- Abstract
- The mammalian target of rapamycin (mTOR) is a serine/threonine kinase that controls a wide spectrum of cellular processes, including cell growth, differentiation, and metabolism. mTOR forms two distinct multiprotein complexes known as mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2), which are characterized by the presence of raptor and rictor, respectively. mTOR controls insulin signaling by regulating several downstream components such as growth factor receptor-bound protein 10 (Grb10), insulin receptor substrate (IRS-1), F-box/WD repeat-containing protein 8 (Fbw8), and insulin like growth factor 1 receptor/insulin receptor (IGF-IR/IR). In addition, mTORC1 and mTORC2 regulate each other through a feedback loop to control cell growth. This review outlines the current understanding of mTOR regulation in insulin signaling in the context of whole body metabolism.
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