Rapid Whole-Brain Gray Matter Imaging Using Single-Slab Three-Dimensional Dual-Echo Fast Spin Echo: A Feasibility Study
- Authors
- Lee, Hyunyeol; Kim, Eung Yeop; Sohn, Chul-Ho; Park, Jaeseok
- Issue Date
- Nov-2017
- Publisher
- WILEY
- Keywords
- magnetic resonance imaging; three dimensional; spin echo; gray matter; double-inversion-recovery
- Citation
- MAGNETIC RESONANCE IN MEDICINE, v.78, no.5, pp.1691 - 1699
- Journal Title
- MAGNETIC RESONANCE IN MEDICINE
- Volume
- 78
- Number
- 5
- Start Page
- 1691
- End Page
- 1699
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/5549
- DOI
- 10.1002/mrm.26910
- ISSN
- 0740-3194
- Abstract
- Purpose: To achieve rapid, high resolution whole-brain gray matter (GM) imaging by developing a novel, single-slab three-dimensional dual-echo fast-spin-echo pulse sequence and GM-selective reconstruction. Methods: Unlike conventional GM imaging that uses time-consuming double-inversion-recovery preparation, the proposed pulse sequence was designed to have two split portions along the echo train, in which the first half was dedicated to yield short inversion recovery (IR)-induced white matter suppression and variable-flip-angle-induced two-step GM signal evolution while the second half cerebrospinal fluid-only signals. Multi-step variable-flip-angle schedules and sampling reordering were optimized to yield high GM signals while balancing cerebrospinal fluid signals between ECHOes. GM-selective images were then reconstructed directly from the weighted subtraction between ECHOes by solving a sparse signal recovery problem. In vivo studies were performed to validate the effectiveness of the proposed method over conventional double-inversion-recovery. Results: The proposed method, while achieving one millimeter isotropic, whole-brain GM imaging within 5.5 min, showed superior performance than conventional double-inversion-recovery in producing GM-only images without apparent artifacts and noise. Conclusion: We successfully demonstrated the feasibility of the proposed method in achieving whole-brain GM imaging in a clinically acceptable imaging time. The proposed method is expected to be a promising alternative to conventional double-inversion-recovery in clinical applications. (C) 2017 International Society for Magnetic Resonance in Medicine.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - 의과대학 > 의학과 > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/5549)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.